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Asian J. Psychiatr., 2023 Apr;82:103473 | https://doi.org/10.1016/j.ajp.2023.103473 Evaluation of changes in neural oscillation after bilateral capsulotomy in treatment refractory obsessive-compulsive disorder using magnetoencephalogram

Jhin goo Chang ^a,1, Do-Won Kim ^b,1, Hyun Ho Jung^c, Won Seok Chang ^c, Chan-Hyung Kim ^d, Se Joo Kim ^d, Jin Woo Chang^c

^aDepartment of Psychiatry, Myongji Hospital, Hanyang University College of Medicine, Goyang, the Republic of Korea
^bSchool of Healthcare and Biomedical Engineering, Chonnam National University, Yeosu, the Republic of Korea
^cDepartment of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine, Seoul, the Republic of Korea
^dDepartment of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, the Republic of Korea

¹These authors have equally contributed to the work.
Correspondence to: Se Joo Kim, Jin Woo Chang

Abstract

Bilateral thermal capsulotomy with magnetic resonance-guided focused ultrasound (MRgFUS-capsulotomy) is a promising treatment option for treatment-refractory obsessive-compulsive disorder (OCD). Herein, we investigated the effects of bilateral thermal capsulotomy with MRgFUS on neural oscillations in treatment-refractory OCD patients. Eight patients underwent resting-state MEG with repeated recordings before and 1 and 6 months after MRgFUS-capsulotomy, and the oscillatory power and phase coherence over the entire cortical sensor area were measured. After MRgFUS-capsulotomy, the high beta band power in the fronto-central and temporal areas decreased at 1 month and remained stable for 6 months. Cortical connectivity of the high beta band gradually decreased over the entire cortical area during the following 6 months. At 1 month, improvement in anxiety and depression symptoms was significantly correlated with changes in high beta band power in both the frontotemporal and temporal areas. The treatment effect of MRgFUS-capsulotomy may be attributed to the cortical high beta band. Our results provide an advanced understanding of the neural mechanisms underlying MRgFUS-capsulotomy and other neuromodulatory interventions for treatment-refractory OCD.

논문정보

형식Research article
게재일2023년 04월 (BRIC 등록일 2023-03-27)
연구진국내 연구진
분야 의약학 > 응용의학

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