한빛사논문
- 조회398
서울대학교병원
Jeong-Min Kim, Reeree Lee, Yongsung Kim, Hae-Bong Jeong, Eun Seong Lee, Hye Ryoun Kim, Kwang-Yeol Park and Ju Won Seok
Department of Neurology, Seoul National University Hospital, Republic of Korea (J.-M.K.). Department of Nuclear Medicine (R.L., J.W.S.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea. Department of Neurology (Y.K., H.-B.J., K.-Y.P.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea. Department of Laboratory Medicine (H.R.K.), Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea. Department of Nuclear Medicine, Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea (E.S.L.).
Correspondence to: Kwang-Yeol Park, MD, PhD, Ju Won Seok, MD, PhD
Abstract
Background:
Elevated metabolic activity of amygdala is known to be related to atherosclerotic cardiovascular event by increasing inflammatory cell production from bone marrow. We tried to identify the factors of metabolic activity in the amygdala, vertebrae, liver, spleen, and internal carotid artery related to the future vascular events after stroke.
Methods:
A total of 110 patients with acute stroke were included (72±10 years of age, 39% women) and underwent whole-body 18F-fluorodeoxyglucose (FDG) positron emission tomography between August 1, 2015 and February 28, 2020. We compared the FDG uptake in the amygdala, vertebrae, liver, spleen, and internal carotid artery between patients with and without recurrent vascular event. Cox proportional hazards model was used to identify factors related to recurrent stroke and vascular event.
Results:
During the median follow-up period of 18 months, 22 patients experienced vascular events, including 15 stroke recurrence. Patients with recurred vascular event had a significantly higher FDG uptake in the amygdala and vertebrae than those without. The Cox proportional hazard model including diabetes, renal function, and carotid stenosis showed that a higher FDG uptake in the amygdala was independently associated with total vascular events (hazard ratio, 3.11 [95% CI, 1.11–8.70]) and higher FDG uptake in the vertebrae with stroke recurrence (hazard ratio, 4.94 [95% CI, 1.29–18.9]).
Conclusions:
The increased metabolic activities of the vertebrae and amygdala are related to future vascular event among stroke survivors.
논문정보
- Research article
- 2023년 01월 (BRIC 등록일 2023-03-27)
- 국내 연구진
- 의약학 > 종양의학
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