한빛사논문
- 조회321
Aleksandra Maruszak,1,† Edina Silajdžić,1,† Hyunah Lee,1,† Tytus Murphy,1 Benjamine Liu,2 Liu Shi,2 Chiara de Lucia,1 Abdel Douiri,3 Evgenia Salta,4,5 Alejo J. Nevado,2 Charlotte E. Teunissen,5 Pieter J. Visser,6,7 Jack Price,1 Henrik Zetterberg,8,9,10,11 Simon Lovestone2,12 and Sandrine Thuret1
1 Department of Basic and Clinical Neuroscience, Institute of Psychiatry Psychology & Neuroscience, King’s College London, London, SE5 9RX, UK
2 Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK
3 Department of Population Health Sciences, King’s College London, London, SE1 1UL, UK
4 Netherlands Institute for Neuroscience, 1105 BA Amsterdam, The Netherlands
5 Neurochemistry Lab and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
6 Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands
7 Department of Neurology, Alzheimer Center, VU University Medical Center, 1081 HZ Amsterdam, The Netherlands
8 Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, S-431 80 Mölndal, Sweden
9 Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, UK
10 Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, S-431 80 Mölndal, Sweden
11 UK Dementia Research Institute at UCL, London, WC1E 6BT, UK
12 Janssen Medical UK, B-2340 Beerse, Belgium
†These authors contributed equally to this work.
Correspondence to: Sandrine Thuret
Abstract
Adult hippocampal neurogenesis is important for learning and memory and is altered early in Alzheimer's disease. As hippocampal neurogenesis is modulated by the circulatory systemic environment, evaluating a proxy of how hippocampal neurogenesis is affected by the systemic milieu could serve as an early biomarker for Alzheimer's disease progression. Here, we used an in vitro assay to model the impact of systemic environment on hippocampal neurogenesis. A human hippocampal progenitor cell line was treated with longitudinal serum samples from individuals with mild cognitive impairment, who either progressed to Alzheimer's disease or remained cognitively stable. Mild cognitive impairment to Alzheimer's disease progression was characterized most prominently with decreased proliferation, increased cell death and increased neurogenesis. A subset of 'baseline' cellular readouts together with education level were able to predict Alzheimer's disease progression. The assay could provide a powerful platform for early prognosis, monitoring disease progression and further mechanistic studies.
논문정보
- Research article
- 2023년 01월 (BRIC 등록일 2023-03-21)
- 국외 연구진
- 생명과학 > 신경생물학
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