한빛사논문
- 조회263
Muhammad Gulfam a, Sung-Han Jo b, Trung Thang Vu a, Israr Ali a, Ali Rizwan a, Soo-Bin Joo a, Sang-Hyug Park b,c, Kwon Taek Lim a,d
aDepartment of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea
bIndustry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Republic of Korea
cMajor of Biomedical Engineering, Division of Smart Healthcare, College of Information Technology and Convergence, Pukyong National University, Busan 48513, Republic of Korea
dDepartment of Display Engineering, Pukyong National University, Busan 48513, Republic of Korea
Correspondence to: S.-H. Park, K. T. Lim
Abstract
In this work, bioorthogonal and photodegradable hydrogels derived from norbornene (Nb) functionalized hyaluronic acid and a water soluble coumarin-based cross-linker possessing terminal tetrazine (Tz) groups, were developed for NIR-responsive release of doxorubicin (DOX). The inverse electron demand Diels-Alder cross-linking reaction between Nb and Tz functionalities formed the hydrogels at physiological conditions, whereas N2 gas liberated during the reaction created pores in the hydrogels. The gelation time ranges (about 5-20 min) and the viscoelastic behavior (G' ~ 346-1380 Pa) demonstrated that the resulting hydrogels were injectable and possessed tunable mechanical properties. Moreover, hydrogels released the encapsulated DOX upon NIR irradiation, owing to the NIR-responsive cleavage of coumarin-ester, and consequently, induced anti-tumor activity in BT-20 cancer cells. Additionally, the hydrogels could be excited at various wavelengths of the visible spectrum and can emit green to red fluorescence, demonstrating their simultaneous photo-responsive drug release and bio-imaging applications.
논문정보
- Research article
- 2023년 03월 (BRIC 등록일 2023-03-17)
- 국내 연구진
- 의약학 > 재생의학
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