한빛사논문
- 조회306
기초과학연구원
Jonathan Sabaté del Río a, Jooyoung Ro a,b, Heejeong Yoon b, Tae-Eun Park b, Yoon-Kyoung Cho a,b
aCenter for Soft and Living Matter, Institute for Basic Science (IBS), Ulsan, 44919, Republic of Korea
bDepartment of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea
Corresponding authors: Tae-Eun Park, Yoon-Kyoung Cho
Abstract
Organs-on-chips (OoCs) are biomimetic in vitro systems based on microfluidic cell cultures that recapitulate the in vivo physicochemical microenvironments and the physiologies and key functional units of specific human organs. These systems are versatile and can be customized to investigate organ-specific physiology, pathology, or pharmacology. They are more physiologically relevant than traditional two-dimensional cultures, can potentially replace the animal models or reduce the use of these models, and represent a unique opportunity for the development of personalized medicine when combined with human induced pluripotent stem cells. Continuous monitoring of important quality parameters of OoCs via a label-free, non-destructive, reliable, high-throughput, and multiplex method is critical for assessing the conditions of these systems and generating relevant analytical data; moreover, elaboration of quality predictive models is required for clinical trials of OoCs. Presently, these analytical data are obtained by manual or automatic sampling and analyzed using single-point, off-chip traditional methods. In this review, we describe recent efforts to integrate biosensing technologies into OoCs for monitoring the physiologies, functions, and physicochemical microenvironments of OoCs. Furthermore, we present potential alternative solutions to current challenges and future directions for the application of artificial intelligence in the development of OoCs and cyber-physical systems. These "smart" OoCs can learn and make autonomous decisions for process optimization, self-regulation, and data analysis.
논문정보
- Review Paper
- 2023년 03월 (BRIC 등록일 2023-03-15)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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