한빛사논문
- 조회708
Bon- Hee Gu1, Jun-Pyo Choi2, Tansol Park3, A-Sol Kim4, Ho Young Jung5, Doo Young Choi5, Sang Jin Lee6, Yoon-Seok Chang2, Myunghoo Kim1,7, Han-Ki Park5
1Life and Industry Convergence Research Institute, Pusan National University, Miryang-si, South Korea
2Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea
3Department of Animal Science and Technology, Chung-Ang University, Anseong-si, South Korea
4Department of Family Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Deagu, South Korea
5Division of Allergy and Clinical Immunology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, South Korea
6Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea
7Department of Animal Science, College of Natural Resources and Life Science, Pusan National University, Miryang-si, South Korea
Bon-Hee Gu and Jun-Pyo Choi contributed equally to this work.
Correspondence: Han-Ki Park, Myunghoo Kim
Abstract
Background: Accumulating evidence suggests that the gut microbiome is associated with asthma. However, altered gut microbiome in adult asthma is not yet well established. We aimed to investigate the gut microbiome profiles of adult asthmatic patients with symptomatic eosinophilic inflammation.
Methods: The 16 s rRNA gene metagenomic analysis of feces in the symptomatic eosinophilic asthma group (EA, n = 28) was compared with the healthy control (HC, n = 18) and the chronic cough control (CC, n = 13). A correlation analysis between individual taxa and clinical markers was performed within the EA group. Changes in the gut microbiome were examined in patients with significant symptom improvement in the EA group.
Results: The relative abundances of Lachnospiraceae and Oscillospiraceae significantly decreased and Bacteroidetes increased in the EA group. Within EA group, Lachnospiraceae was negatively correlated with indicators of type 2 inflammation and lung function decline. Enterobacteriaceae and Prevotella was positively associated with type 2 inflammation and lung function decline, respectively. The abundance of predicted genes associated with amino acid metabolism and secondary bile acid biosynthesis was diminished in the EA group. These functional gene family alterations could be related to gut permeability, and the serum lipopolysaccharide concentration was actually high in the EA group. EA patients with symptom improvement after 1 month did not show a significant change in the gut microbiome.
Conclusions: Symptomatic eosinophilic adult asthma patients showed altered the gut microbiome composition. Specifically, a decrease in commensal clostridia was observed, and a decrease in Lachnospiraceae was correlated with blood eosinophilia and lung function decline.
논문정보
- Research article
- 2023년 02월 (BRIC 등록일 2023-03-14)
- 국내 연구진
- 의약학 > 면역의학
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