이충성 (UCLA, 선문대학교, 순천향대학교) | 한빛사논문 > 한빛사

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UCLA, 선문대학교, 순천향대학교

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Prog. Mater. Sci., Available online 3 February 2023 | https://doi.org/10.1016/j.pmatsci.2023.101087 Materials-based nanotherapeutics for injured and diseased bone

Chung-Sung Lee ^a,b,c,1, Rajendra K. Singh ^d,e,1, Hee Sook Hwang ^a,f,1, Na-Hyun Lee ^d,e, Amal George Kurian ^d,e, Jung-Hwan Lee^d,e,g,h,j,k, Hye Sung Kim ^d,k, Min Lee ^a,i, Hae-Won Kim ^d,e,g,h,j,k

^aDivision of Advanced Prosthodontics, University of California Los Angeles, CA 90095, USA
^bDepartment of Pharmaceutical Engineering and Biotechnology, Sun Moon University, Asan 31460, Republic of Korea
^cDepartment of Pharmaceutical Engineering, Soonchunhyang University, Asan 31538, Republic of Korea
^dInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea
^eDepartment of Nanobiomedical Science and BK21 NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea
^fDepartment of Pharmaceutical Engineering, Dankook University, Cheonan 31116, Republic of Korea
^gDepartment of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Republic of Korea
^hCell & Matter Institute, Dankook University, Cheonan 31116, Republic of Korea
ⁱDepartment of Bioengineering, University of California Los Angeles, CA 90095, USA
^jUCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan 31116, Republic of Korea
^kMechanobiology Dental Medicine Research Center, Dankook University, Cheonan, 31116, Republic of Korea

1These authors equally contributed to this work.
Corresponding authors : Hye Sung Kim, Min Lee, Hae-Won Kim

Abstract

Severe injuries and diseases of bone tissue caused by congenital disorder, extrinsic trauma, infection, and osteosarcoma resection face significant challenges for complete recovery. The current treatment options with therapeutic molecules (e.g., drugs, proteins, genetic molecules) often involve vector-borne infection, restrictive availability, donor deficiency, and immune rejection, whereas the materials-based nanotherapeutics can tackle these issues. Nanotherapeutics can secure the stability and activity of cargo molecules, allow their controlled release, and even target the specific cells and organelles, all of which eventually improve the in vivo efficacy while relieving the off-target concerns. Here we systematically review the recent progress in materials-based nanotherapeutics for the treatment of injured and diseased bone, highlighting the processing nanotechnologies and delivery strategies of various classes of therapeutic molecules that intervene specific cells and intracellular signaling pathways. Nanotherapeutics combined with three-dimensional matrices are also underscored that can recruit endogenous cells and sequester intrinsic therapeutic molecules, ultimately supporting and boosting the microenvironment for regenerative process. Future aspects in the development of nanotherapeutics approach and clinical availability are also discussed.

논문정보

형식Research article
게재일2023년 02월 (BRIC 등록일 2023-03-14)
연구진국내(교신)+국외 연구진
분야 의약학 > 재생의학

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