한빛사논문
- 조회369
Salma Nabila, S.Gz1,2, Ji-Eun Kim, BSc1,2, Jaesung Choi, PhD2,3, JooYong Park, PhD1,2,4, Aesun Shin, PhD5,6, Sang-Ah Lee, PhD7, Daehee Kang, PhD1,5,6,8 , Ji-Yeob Choi, PhD1,2,3,6,*
1Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea
2BK21plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, Republic of Korea
3Institute of Health Policy and Management, Seoul National University Medical Research Center, Seoul, Republic of Korea
4Department of Big Data Medical Convergence, Eulji University, Seongnam-Si, Gyeonggi-Do, Korea
5Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
6Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
7Department of Preventive Medicine, Kangwon National University School of Medicine, Gangwon, Korea
8Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Korea
Corresponding author: Ji-Yeob Choi, PhD
Abstract
Objective: To examine the associations between modifiable risk factors and glycemic status changes in individuals with prediabetes.
Research design and methods: A total of 10,358 individuals with prediabetes defined by their fasting blood glucose and HbA1c levels from the Health Examinees-Gem study were included in the present study. Modifiable factors, including BMI, abdominal obesity, smoking status, physical activity, alcohol consumption, diet quality, hypertension, and dyslipidemia, were examined to determine their associations with changes in glycemic status during follow-up. In addition, modifiable-factor scores were calculated, and their association with changes in glycemic status was also analyzed.
Results: The median follow-up time for this study was 4 years (range, 1-7 years). BMI ≥25 kg/m2 (adjusted odds ratio [OR] 0.71 [95% CI 0.63-0.79]), abdominal obesity (OR 0.76 [95% CI 0.68-0.86]), heavy drinking (OR 0.74 [95% CI 0.60-0.91]), hypertension (OR 0.71 [95% CI 0.64-0.79]), and dyslipidemia (OR 0.78 [95% CI 0.70-0.85]) were associated with a lower possibility of normoglycemia reversion. BMI ≥25 kg/m2 (OR 1.58 [95% CI 1.29-1.94]), abdominal obesity (OR 1.31 [95% CI 1.11-1.55]), current smoking (OR 1.43 [95% CI 1.07-1.91]), and hypertension (OR 1.26 [95% CI 1.07-1.49]) were associated with a higher probability of type 2 diabetes progression. Having more favorable modifiable factors was also associated with normoglycemia reversion (OR 1.46 [95% CI 1.30-1.64]) and type 2 diabetes progression (OR 0.62 [95% CI 0.49-0.77]).
Conclusions: More favorable modifiable factors were related to a higher probability of returning to normoglycemia and a lower probability of progression to type 2 diabetes.
논문정보
- Research article
- 2023년 03월 (BRIC 등록일 2023-03-10)
- 국내 연구진
- 의약학 > 응용의학
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