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Nat. Prod. Rep., 2023 Jan 24 | https://doi.org/10.1039/D2NP00078D Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production

Jeong Sang Yi,^†a Jung Min Kim,^†a Yeon Hee Ban^*b and Yeo Joon Yoon^*a

^aNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea
^bCollege of Biomedical Science, Kangwon National University, Chuncheon, Republic of Korea

^†These authors have contributed equally.
^*Corresponding authors: Yeon Hee Ban, Yeo Joon Yoon

Abstract

Polyketides derived from actinomycetes are a valuable source of eco-friendly biochemical insecticides. The development of new insecticides is urgently required, as the number of insects resistant to more than one drug is rapidly increasing. Moreover, significant enhancement of the production of such biochemical insecticides is required for economical production. There has been considerable improvement in polyketide insecticidal agent production and development of new insecticides. However, most commercially important biochemical insecticides are synthesized by modular type I polyketide synthases (PKSs), and their structural complexities make chemical modification challenging. A detailed understanding of the biosynthetic mechanisms of potent polyketide insecticides and the structure-activity relationships of their analogs will provide insight into the comprehensive design of new insecticides with improved efficacies. Further metabolic engineering and combinatorial biosynthesis efforts, reinvigorated by synthetic biology, can eventually produce designed analogs in large quantities. This highlight reviews the biosynthesis of representative insecticides produced by modular type I PKSs, such as avermectin, spinosyn, and spectinabilin, and their insecticidal properties. Metabolic engineering and combinatorial biosynthetic strategies for the development of high-yield strains and analogs with insecticidal activities are emphasized, proposing a way to develop a next-generation insecticide.

논문정보

형식Review Paper
게재일2023년 01월 (BRIC 등록일 2023-03-09)
연구진국내 연구진
분야 생명과학 > 생화학

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