Natasha Christabella Sutopo (성균관대학교) | 한빛사논문 > 한빛사

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Natasha Christabella SutopoNatasha Christabella Sutopo

성균관대학교

Biochim. Biophys. Acta-Rev. Cancer, 2023 Feb 24;1878(3):188865 | https://doi.org/10.1016/j.bbcan.2023.188865 Role of histone methylation in skin cancers: Histone methylation-modifying enzymes as a new class of targets for skin cancer treatment

Natasha Christabella Sutopo ^a, Ji Hye Kim ^b,c, Jae Youl Cho ^a,b,c

^aDepartment of Biocosmetics, Sungkyunkwan University, Suwon 16419, Republic of Korea
^bDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea
^cBiomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Republic of Korea

Corresponding authors: Ji Hye Kim, Jae Youl Cho

Abstract

Histone methylation, one of the most prominent epigenetic modifications, plays a vital role in gene transcription, and aberrant histone methylation levels cause tumorigenesis. Histone methylation is a reversible enzyme-dependent reaction, and histone methyltransferases and demethylases are involved in this reaction. This review addresses the biological and clinical relevance of these histone methylation-modifying enzymes for skin cancer. In particular, the roles of histone lysine methyltransferases, histone arginine methyltransferase, lysine-specific demethylases, and JmjC demethylases in skin cancer are discussed in detail. In addition, we summarize the efficacy of several epigenetic inhibitors targeting histone methylation-modifying enzymes in cutaneous cancers, such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. In conclusion, we propose histone methylation-modifying enzymes as novel targets for next-generation pharmaceuticals in the treatment of skin cancers and further provide a rationale for the development of epigenetic drugs (epidrugs) that target specific histone methylases/demethylases in cutaneous tumors.

논문정보

형식Review Paper
게재일2023년 02월 (BRIC 등록일 2023-03-09)
연구진국내 연구진
분야 생명과학 > 면역학

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