한빛사논문
- 조회183
Ling Huang 1, Wanting Su 1, Lin Zhu 1, Jiangfeng Li 1, Wei Quan 1, Juyoung Yoon 2, Weiying Lin 1
1Guangxi Key Laboratory of Electrochemical Energy Materials, Institute of Optical Materials and Chemical Biology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, P. R. China.
2Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Korea.
CORRESPONDING AUTHORS: Juyoung Yoon, Weiying Lin
Abstract
Neutrophil elastase (NE) plays a key role in chronic inflammation and acute responses to infection and injury. Effective disease interventions thus call for precise identification of NE to aid the clinical treatment of such diseases. However, the detection process suffers from the interference of structural changes of NE. Herein, we introduce a molecular probe with high biocompatibility to overcome the interference, which was achieved by combining theoretical calculations and experimental studies, that permits highly specific and sensitive detection of NE in cells and in vivo. The upregulated NE accumulation was specifically measured in inflammation by ratiometric photoacoustic and near-infrared fluorescence imaging, providing a new method for developing more specific fluorogenic probes for other enzymes.
논문정보
- Research article
- 2023년 02월 (BRIC 등록일 2023-03-02)
- 국내(교신)+국외 연구진
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