한빛사논문
- 조회228
Neha Kaushik a,1, Sarmistha Mitra b,1, Eun Jung Baek c, Linh Nhat Nguyen d,e, Pradeep Bhartiya d, June Hyun Kim a, Eun Ha Choi d, Nagendra Kumar Kaushik d
aDepartment of Biotechnology, College of Engineering, The University of Suwon, Hwaseong 18323, Korea
bDepartment of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Korea
cDepartment of Laboratory Medicine, College of Medicine, Hanyang University, Seoul 04763, Korea
dDepartment of Electrical and Biological Physics, Plasma Bioscience Research Center, Kwangwoon University, Seoul 01897, Korea
eLaboratory of Plasma Technology, Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi 100000, Viet Nam
1These authors equally contributed to this work.
Corresponding authors: Eun Ha Choi, Nagendra Kumar Kaushik
Abstract
Background: Outbreaks of airborne viral infections, such as COVID-19, can cause panic regarding other severe respiratory syndrome diseases that may develop and affect public health. It is therefore necessary to develop control methods that offer protection against such viruses.
Aim of review: To identify a feasible solution for virus deactivation, we critically reviewed methods of generating reactive oxygen species (ROS), which can attack a wide range of molecular targets to induce antiviral activity, accounting for their flexibility in facilitating host defense mechanisms against a comprehensive range of pathogens. Recently, the role of ROS in microbial decontamination has been critically investigated as a major topic in infectious diseases. ROS can eradicate pathogens directly by inducing oxidative stress or indirectly by promoting pathogen removal through numerous non-oxidative mechanisms, including autophagy, T-cell responses, and pattern recognition receptor signaling.
Key scientific concepts of review: In this article, we reviewed possible methods for the in vitro generation of ROS with antiviral activity. Furthermore, we discuss, in detail, the novel and environmentally friendly cold plasma delivery system in the destruction of viruses. This review highlights the potential of ROS as therapeutic mediators to modernize current techniques and improvement on the efficiency of inactivating SARS-CoV2 and other viruses.
논문정보
- Review Paper
- 2023년 01월 (BRIC 등록일 2023-03-02)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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