한빛사논문
- 조회477
Steven S. Hou1, Joyce Yang1, Jeong Heon Lee2, Yeseo Kwon 1, Maria Calvo-Rodriguez1, Kai Bao2, Sung Ahn 2, Satoshi Kashiwagi 2, Anand T. N. Kumar3, Brian J. Bacskai 1 & Hak Soo Choi 2
1Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
2Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Corresponding authors : Correspondence to Brian J. Bacskai or Hak Soo Choi.
Abstract
Non-invasive methods for the in vivo detection of hallmarks of Alzheimer's disease can facilitate the study of the progression of the disease in mouse models and may enable its earlier diagnosis in humans. Here we show that the zwitterionic heptamethine fluorophore ZW800-1C, which has peak excitation and emission wavelengths in the near-infrared optical window, binds in vivo and at high contrast to amyloid-β deposits and to neurofibrillary tangles, and allows for the microscopic imaging of amyloid-β and tau aggregates through the intact skull of mice. In transgenic mouse models of Alzheimer's disease, we compare the performance of ZW800-1C with that of the two spectrally similar heptamethine fluorophores ZW800-1A and indocyanine green, and show that ZW800-1C undergoes a longer fluorescence-lifetime shift when bound to amyloid-β and tau aggregates than when circulating in blood vessels. ZW800-1C may prove advantageous for tracking the proteinic aggregates in rodent models of amyloid-β and tau pathologies.
논문정보
- Research article
- 2023년 02월 (BRIC 등록일 2023-02-24)
- 국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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