한빛사논문
- 조회288
Seungmin Son1,2*, Jong Hee Im1,3*, Jae-Heung Ko4 and Kyung-Hwan Han3,5
1Department of Life Sciences, Korea University, 145 Anamro, Sungbuk-gu, Seoul 02841, Korea
2National Institute of Agricultural Sciences, Rural Development Administration, Jeonju, 54874, Korea
3Department of Horticulture, Michigan State University, East Lansing, MI 48824, USA
4Department of Plant & Environmental New Resources, College of Life Science and Graduate School of Biotechnology, Kyung Hee University, Yongin-si, Gyeonggi-do 17104, Korea
5Department of Forestry, Michigan State University, East Lansing, MI 48824, USA
*SS and JHI contributed equally to this work.
Author for correspondence: Kyung-Hwan Han
Abstract
Cellular sugar starvation and/or energy deprivation serves as an important signaling cue for the live cells to trigger the necessary stress adaptation response. When exposed to cellular energy stress (ES) conditions, the plants reconfigure metabolic pathways and rebalance energy status while restricting vegetative organ growth. Despite the vital importance of this ES-induced growth restriction, the regulatory mechanism underlying the response remains largely elusive in plants. Using plant cell- and whole plant-based functional analyses coupled with extended genetic validation, we show that cellular ES-activated SNF1-related protein kinase 1 (SnRK1.1) directly interacts with and phosphorylates E2Fa transcription factor, a critical cell cycle regulator. Phosphorylation of E2Fa by SnRK1.1 leads to its proteasome-mediated protein degradation, resulting in S-phase repression and organ growth restriction. Our findings show that ES-dependently activated SnRK1.1 adjusts cell proliferation and vegetative growth for plants to cope with constantly fluctuating environments.
논문정보
- Research article
- 2023년 02월 (BRIC 등록일 2023-03-02)
- 국내+국외 연구진
- 생명과학 > 식물학
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