한빛사논문
- 조회369
Wonok Kang1,2, Chanyang Ju2,3, Jaesoon Joo4, Jiho Lee2,3, Young-Min Shon4,5 & Sung-Min Park1,2,3,6,7,8
1School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
2Medical Device Innovation Center, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
3Department of Convergence IT Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
4Biomedical Engineering Research Center, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, South Korea.
5Department of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Republic of Korea.
6Department of Electrical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
7Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
8Institute of Convergence Science, Yonsei University, Seoul 03722, Republic of Korea.
Corresponding authors : Correspondence to Young-Min Shon or Sung-Min Park.
Abstract
Direct electrical stimulation of the seizure focus can achieve the early termination of epileptic oscillations. However, direct intervention of the hippocampus, the most prevalent seizure focus in temporal lobe epilepsy is thought to be not practicable due to its large size and elongated shape. Here, in a rat model, we report a sequential narrow-field stimulation method for terminating seizures, while focusing stimulus energy at the spatially extensive hippocampal structure. The effects and regional specificity of this method were demonstrated via electrophysiological and biological responses. Our proposed modality demonstrates spatiotemporal preciseness and selectiveness for modulating the pathological target region which may have potential for further investigation as a therapeutic approach.
논문정보
- Research article
- 2022년 12월 (BRIC 등록일 2023-02-17)
- 국내 연구진
- 의약학 > 신경의학
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