한빛사논문
- 조회407
Taejeong Kim 1, Hyun Jin Kim 2, Wonseok Choi 3, Yeong Mi Lee1, Jung Hyun Pyo 2, Junseok Lee1, Jeesu Kim3, Jihoon Kim4, Joung-Hun Kim2, Chulhong Kim 3,5 & Won Jong Kim 1,5,6
1Department of Chemistry, Postech-Catholic Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
2Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
3Department of Electrical Engineering and Creative IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
4Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
5School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
6OmniaMed Co., Ltd., Pohang, Republic of Korea.
Corresponding author : Correspondence to Won Jong Kim.
Abstract
Deep brain stimulation via implanted electrodes can alleviate neuronal disorders. However, its applicability is constrained by side effects resulting from the insertion of electrodes into the brain. Here, we show that systemically administered piezoelectric nanoparticles producing nitric oxide and generating direct current under high-intensity focused ultrasound can be used to stimulate deep tissue in the brain. The release of nitric oxide temporarily disrupted tight junctions in the blood-brain barrier, allowing for the accumulation of the nanoparticles into brain parenchyma, and the piezoelectrically induced output current stimulated the release of dopamine by dopaminergic neuron-like cells. In a mouse model of Parkinson's disease, the ultrasound-responsive nanoparticles alleviated the symptoms of the disease without causing overt toxicity. The strategy may inspire the development of other minimally invasive therapies for neurodegenerative diseases.
논문정보
- Research article
- 2022년 12월 (BRIC 등록일 2023-03-06)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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