한빛사논문
- 조회426
Uijung Yong 1, Donghwan Kim 2, Hojoong Kim 3, Dong Gyu Hwang 2, Sungkeon Cho 4, Hyoryung Nam 1, Sejin Kim 4, Taeyeong Kim 5, Unyong Jeong 5, Keehoon Kim 4, Wan Kyun Chung 4, Woon-Hong Yeo 3,6,7, Jinah Jang 1,2,4,8
1Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 37666, Republic of Korea.
2School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang, 37666, Republic of Korea.
3George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
4Department of Mechanical Engineering, POSTECH, Pohang, 37673, Republic of Korea.
5Department of Materials Science and Engineering, POSTECH, Pohang, 37673, Republic of Korea.
6Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA, 30332, USA.
7IEN Center for Human-Centric Interfaces and Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
8Institute for Convergence Research and Education in Advanced Technology, Yonsei University, Seoul, 03722, Republic of Korea.
CORRESPONDING AUTHORS : Woon-Hong Yeo, Jinah Jang
Abstract
Drug-induced cardiotoxicity is regarded as a major hurdle in the early stages of drug development. Although there are various methods for preclinical cardiotoxicity tests, they cannot completely predict the cardiotoxic potential of a compound due to the lack of physiological relevance. Recently, 3D engineered heart tissue (EHT) has been used to investigate cardiac muscle functions as well as pharmacological effects by exhibiting physiological auxotonic contractions. However, there is still no adequate platform for continuous monitoring to test acute and chronic pharmacological effects in vitro. Here, a biohybrid 3D printing method for fabricating a tissue-sensor platform, composed of a bipillar-grafted strain gauge sensor and EHT, is first introduced. Two pillars are three-dimensionally printed as grafts onto a strain gauge-embedded substrate to promote the EHT contractility and guide the self-assembly of the EHTs along with the strain gauge. In addition, the integration of a wireless multi-channel electronic system allows for continuous monitoring of the EHT contractile force by the tissue-sensor platform and, ultimately, for the observation of the acute and chronic drug effects of cardiotoxicants. In summary, biohybrid 3D printing technology is expected to be a potential fabrication method to provide a next-generation tissue-sensor platform for an effective drug development process.
논문정보
- Research article
- 2022년 12월 (BRIC 등록일 2023-02-13)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
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