백진희 (기초과학연구원, Stanford University) | 한빛사논문 > 한빛사

한빛사논문

조회303

기초과학연구원, Stanford University

Neuron, 2023 Feb 1;111(3):418-429.e4 | https://doi.org/10.1016/j.neuron.2022.11.001 Hemispherically lateralized rhythmic oscillations in the cingulate-amygdala circuit drive affective empathy in mice

Seong-Wook Kim ^1,9, Minsoo Kim ^1,2,9, Jinhee Baek ^1,9, Charles-Francois Latchoumane ¹, Gireesh Gangadharan ³, Yongwoo Yoon ¹, Duk-Soo Kim ⁴, Jin Hyung Lee ^2,5,6,7, Hee-Sup Shin ^1,8,10

¹Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon 34126, Republic of Korea
²Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
³Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India
⁴Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan-Si 31151, Republic of Korea
⁵Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
⁶Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA
⁷Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
⁸SL Bigen, Incheon 21983, Republic of Korea
⁹These authors contributed equally
¹⁰Lead contact

Corresponding author: Hee-Sup Shin

Abstract

Observational fear, a form of emotional contagion, is thought to be a basic form of affective empathy. However, the neural process engaged at the specific moment when socially acquired information provokes an emotional response remains elusive. Here, we show that reciprocal projections between the anterior cingulate cortex (ACC) and basolateral amygdala (BLA) in the right hemisphere are essential for observational fear, and 5-7 Hz neural oscillations were selectively increased in those areas at the onset of observational freezing. A closed-loop disruption demonstrated the causal relationship between 5-7 Hz oscillations in the cingulo-amygdala circuit and observational fear responses. The increase/decrease in theta power induced by optogenetic manipulation of the hippocampal theta rhythm bi-directionally modulated observational fear. Together, these results indicate that hippocampus-dependent 5-7 Hz oscillations in the cingulo-amygdala circuit in the right hemisphere are the essential component of the cognitive process that drives empathic fear, but not freezing, in general.

논문정보

형식Research article
게재일2023년 02월 (BRIC 등록일 2023-02-28)
연구진국내(교신)+국외 연구진
분야 생명과학 > 신경생물학

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