한빛사논문
- 조회311
Jin-Young Jeong a, So-ong Kim b, Sunwoo Bang a, Yoonji Choi a, Junghyun Shin a, Danmin Choi a, Sang-Eun Lee a, Tai Hyun Park b,c, Seunghun Hong d
aDepartment of Physics and Astronomy, Seoul National University, Seoul, 08826, South Korea
bSchool of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, 08826, South Korea
cInterdisciplinary Program in Bioengineering, Seoul National University, Seoul, 08826, South Korea
dDepartment of Physics and Astronomy, and the Institute of Applied Physics, Seoul National University, Seoul, 08826, South Korea
Corresponding authors: Tai Hyun Park, Seunghun Hong
Abstract
Inspired by an adaptive immune system, we have developed a bioelectronic sensing platform which relies on nanovesicles for a signal amplification and can be easily adapted for the detection of new food allergens. In this work, nanovesicles with anti-immunoglobulin E (anti-IgE) antibody receptors were extracted from immune cells and immobilized on a carbon nanotube-based transistor to build a highly sensitive and selective biosensing platform. Our sensor could detect peanut allergen, arachis hypogaea 2 (Ara h 2), down to 0.1 fM and selectively discriminate target allergens in real food samples such as peanut and egg white. As a proof of concept, we demonstrated the detection of different target molecules using the same nanovesicles linked with different antibodies. Our sensor platform was also utilized to quantitatively evaluate the effect of allergy drug such as cromolyn. In this regard, our strategy can be utilized for basic research and versatile applications in food and pharmacological industries.
논문정보
- Research article
- 2023년 02월 (BRIC 등록일 2023-03-06)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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