한빛사논문
- 조회323
충남대학교병원
So Yeon Jeon 1,2, Min Soo Byun 3,4, Dahyun Yi 5, Gijung Jung 3, Jun-Young Lee 6, Yu Kyeong Kim 7, Chul-Ho Sohn 8,9, Koung Mi Kang 9, Yu Jin Lee 3,4, Dong Young Lee 3,4,5; KBASE Research Group
1Department of Psychiatry, Chungnam National University Hospital, Daejeon, Republic of Korea.
2Department of Psychiatry, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
3Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
4Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
5Institute of Human Behavioral Medicine, Medical Research Centre, Seoul National University, Seoul, South Korea.
6Department of Neuropsychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.
7Department of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea.
8Department of Radiology, Seoul National University College of Medcine, Seoul, South Korea.
9Department of Radiology, Seoul National University Hospital, Seoul, South Korea.
CORRESPONDING AUTHOR : Dong Young Lee MD, PhD
Abstract
Aim: The neurobiological substrates underlying the relationship of circadian rest-activity rhythm (RAR) alteration with accelerated late-life cognitive decline are not clearly understood. In the present study, the longitudinal relationship of objectively measured circadian RAR with in vivo Alzheimer disease (AD) pathologies and cerebrovascular injury was investigated in older adults without dementia.
Methods: The present study included 129 participants without dementia who participated in the KBASE (Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease) cohort. All participants underwent actigraphy at baseline and two consecutive [11 C] Pittsburgh compound-B positron emission tomography (PET), [18 F] fluorodeoxyglucose-PET, magnetic resonance imaging, and Mini-Mental State Examination (MMSE) at baseline and at a 2-year follow-up assessment. The associations of circadian RAR with annualized change in neuroimaging measures including global amyloid-beta retention, AD-signature region cerebral glucose metabolism (AD-CM), and white matter hyperintensity volume were examined.
Results: Delayed acrophase at baseline was significantly associated with greater annualized decline of AD-CM over a 2-year period, but not with that of other neuroimaging measures. In contrast, other circadian RAR parameters at baseline had no association with annualized change of any neuroimaging measures. Annualized decline of AD-CM was also significantly positively associated with the annual change in MMSE scores. Furthermore, a mediation analysis showed that greater reduction in AD-CM mediated the effect of delayed acrophase at baseline on faster decline of MMSE score.
Conclusion: The findings indicate that delayed acrophase in late life may cause or predict hypometabolism at AD-signature brain regions, which underlies cognitive decline in the near future.
논문정보
- Research article
- 2022년 12월 (BRIC 등록일 2023-03-06)
- 국내 연구진
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