한빛사논문
Ling Li a,b, Fatima Zahra Rami a,b, Bo Mi Lee a,b, Woo-Sung Kim a,b, Chae Yeong Kang a,b, Sung-Wan Kim c, Bong Ju Lee d, Jung Jin Kim e, Je-Chun Yu f, Kyu Young Lee g, Seung-Hee Won h, Seung-Hwan Lee i, Seung-Hyun Kim j, Shi Hyun Kang k, Eui Tae Kim l, Young-Chul Chung a,b
aDepartment of Psychiatry, Jeonbuk National University Medical School, Jeonju 54907, South Korea
bResearch Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea
cDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, South Korea
dDepartment of Psychiatry, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea
eDepartment of Psychiatry, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea
fDepartment of Psychiatry, Eulji University School of Medicine, Eulji University Hospital, Daejeon, South Korea
gDepartment of Psychiatry, Eulji University School of Medicine, Eulji General Hospital, Seoul, South Korea
hDepartment of Psychiatry, Kyungpook National University School of Medicine, Daegu, South Korea
iDepartment of Psychiatry, Inje University College of Medicine, Goyang, South Korea
jDepartment of Psychiatry, Korea University College of Medicine, Guro Hospital, Seoul, South Korea
kDepartment of Social Psychiatry and Rehabilitation, National Center for Mental Health, Seoul, South Korea
lDepartment of Psychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea
Corresponding author : Young-Chul Chung
Abstract
To promote recovery in psychosis, targeting modifiable factors related to recovery is critical. Using more strict definition of full recovery, we examined predictors for recovery in patients with early stage schizophrenia spectrum disorders (SSD) followed up to 6.5 years. The target subjects were 375 patients with early stage SSD who had been over at least 1-year after registration and evaluated. The criteria for full recovery were having the score of the Positive and Negative Syndrome Scale (PANSS) 8-item ≤ 2 and adequate functional recovery for at least 1-year. We performed univariate Cox and stepwise Cox regression in both total and acute patients. In stepwise Cox regression, several independent predictors for recovery, i.e., negative symptoms of the PANSS, duration of untreated psychosis (DUP) and non-professional job were identified in patients with early stage SSD. In acute patients, other factors such as professional job and subjective well-being under neuroleptics were more important. The present study identified independent predictors for recovery modifiable by various psychosocial intervention and early intervention services. Moreover, it highlights the need of providing different treatment strategies depending on clinical status.
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