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조회697

POSTECH

Adv. Healthc. Mater., 2022 Dec 20;e2201697 | https://doi.org/10.1002/adhm.202201697 Peripheral Microneedle Patch for First-Aid Hemostasis

Jungho Lee ¹, Sebin Park ¹, Phuong Thao Le ², Geunho Lee¹, Hyoun Wook Lee ³, Gaeun Yun¹, Juhyeong Jeon ¹, Jeongwoo Park ^2,4, Duy Tho Pham ^1,5, Young Sook Park ⁶, Hoon Lim ⁷, Chulhong Kim ^1,2,4,8,9, Tae Sik Hwang ¹⁰, Seung Whan Kim ⁵, Geunbae Lim ^1,2,11

¹Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.
²School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.
³Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, 51353, Republic of Korea.
⁴Medical Device Innovation Center, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.
⁵Department of Emergency Medicine, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
⁶Department of Physical Rehabilitation Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, 51353, Republic of Korea.
⁷Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, 14584, Republic of Korea.
⁸Department of Convergence IT Engineering, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.
⁹Department of Electrical Engineering, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.
¹⁰Department of Emergency Medicine, Yonsei University College of Medicine, Yongin Severance Hospital, Yongin, 16995, Republic of Korea.
¹¹Institute for Convergence Research and Education in Advanced Technology, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

CORRESPONDING AUTHORS: Tae Sik Hwang, Seung Whan Kim, Geunbae Lim

Abstract

Despite the minimized puncture sizes and high efficiency, microneedle (MN) patches have not been used to inject hemostatic drugs into bleeding wounds because they easily destroy capillaries when a tissue is pierced. In this study, a shelf-stable dissolving MN patch is developed to prevent rebleeding during an emergency treatment. A minimally and site-selectively invasive hemostatic drug delivery system is established by using a peripheral MN (p-MN) patch that does not directly intrude the wound site but enables topical drug absorption in the damaged capillaries. The invasiveness of MNs is histologically examined by using a bleeding liver of a Sprague-Dawley (SD) rat as an extreme wound model in vivo. The skin penetration force is quantified to demonstrate that the administration of the p-MN patch is milder than that of the conventional MN patch. Hemostatic performance is systematically studied by analyzing bleeding weight and time and comparing them with that of conventional hemostasis methods. The superior performance of a p-MN for the heparin-pretreated SD rat model is demonstrated by intravenous injection in vivo.

논문정보

형식Research article
게재일2022년 12월 (BRIC 등록일 2023-02-07)
연구진국내 연구진
분야 생명과학 > 분자생물학

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