한빛사논문
- 조회424
Minh Tran1,2,3, Chaejeong Heo1,2,4, Luke P. Lee1,2,5,6,7* and Hansang Cho1,2,3*
1Institute of Quantum Biophysics, Sungkyunkwan University, Suwon 16419, Korea.
2Department of Biophysics, Sungkyunkwan University, Suwon 16419, Korea.
3Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon 16419, Korea.
4Center for Integrated Nanostructure Physics, Institute for Basic Science, Suwon 16419, Korea.
5Department of Bioengineering, University of California at Berkeley, Berkeley, CA, USA.
6Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA, USA.
7Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA 02115, USA
*Corresponding authors : Correspondence to Luke P. Lee or Hansang Cho.
Abstract
The human blood-brain barrier (BBB) is a unique multicellular structure that is in critical demand for fundamental neuroscience studies and therapeutic evaluation. Despite substantial achievements in creating in vitro human BBB platforms, challenges in generating specifics of physiopathological relevance are viewed as impediments to the establishment of in vitro models. In this review, we provide insight into the development and deployment of in vitro BBB models that allow investigation of the physiology and pathology of neurological therapeutic avenues. First, we highlight the critical components, including cell sources, biomaterial glue collections, and engineering techniques to reconstruct a miniaturized human BBB. Second, we describe recent breakthroughs in human mini-BBBs for investigating biological mechanisms in neurology. Finally, we discuss the application of human mini-BBBs to medical approaches. This review provides strategies for understanding neurological diseases, a validation model for drug discovery, and a potential approach for generating personalized medicine.
논문정보
- Review Paper
- 2022년 12월 (BRIC 등록일 2023-02-08)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 뇌인지과학
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