한빛사논문
- 조회668
Cho Rim Kim1, Jae Hoon Han1, Min Ji Kim1, Myoung Ju Kim1, Se-Na Kim2, Yong Chan Cho1, Han Bi Ji1, Chang Hee Min2, Cheol Lee3, Young Bin Choy1,2,4
1Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, Republic of Korea
2Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, Republic of Korea
3Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
4Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Republic of Korea
Correspondence: Young Bin Choy
Abstract
Prompt administration of first-aid drugs can save lives during medical emergencies such as anaphylaxis and hypoglycemia. However, this is often performed by needle self-injection, which is not easy for patients under emergency conditions. Therefore, we propose an implantable device capable of on-demand administration of first-aid drugs (i.e., the implantable device with a magnetically rotating disk [iMRD]), such as epinephrine and glucagon, via a noninvasive simple application of the magnet from the outside skin (i.e., the external magnet). The iMRD contained a disk embedded with a magnet, as well as multiple drug reservoirs that were sealed with a membrane, which was designed to rotate at a precise angle only when the external magnet was applied. During this rotation, the membrane on a designated single-drug reservoir was aligned and torn to expose the drug to the outside. When implanted in living animals, the iMRD, actuated by an external magnet, delivers epinephrine and glucagon, similar to conventional subcutaneous needle injections.
논문정보
- Research article
- 2023년 02월 (BRIC 등록일 2023-02-02)
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