한빛사논문
- 조회352
Tae Yeon Kim1, Jee Won Mok2, Sang Hoon Hong 1, Sang Hoon Jeong1, Hyunsik Choi3, Sangbaie Shin3, Choun-Ki Joo2 & Sei Kwang Hahn 1,3
1Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Korea.
2CK St. Mary’s Eye Center, CK building, 559, Gangnam-daero, Seocho-gu, Seoul 06531, Korea.
3PHI BIOMED Co., 168, Yeoksam-ro, Gangnam-gu, Seoul 06248, Korea.
Corresponding author : Correspondence to Sei Kwang Hahn.
Abstract
Glaucoma is one of the irreversible ocular diseases that can cause vision loss in some serious cases. Although Triggerfish has been commercialized for monitoring intraocular pressure in glaucoma, there is no smart contact lens to monitor intraocular pressure and take appropriate drug treatment in response to the intraocular pressure levels. Here, we report a precisely integrated theranostic smart contact lens with a sensitive gold hollow nanowire based intraocular pressure sensor, a flexible drug delivery system, wireless power and communication systems and an application specific integrated circuit chip for both monitoring and control of intraocular pressure in glaucoma. The gold hollow nanowire based intraocular pressure sensor shows high ocular strain sensitivity, chemical stability and biocompatibility. Furthermore, the flexible drug delivery system can be used for on-demand delivery of timolol for intraocular pressure control. Taken together, the intraocular pressure levels can be successfully monitored and controlled by the theranostic smart contact lens in glaucoma induced rabbits. This theranostic smart contact lens would be harnessed as a futuristic personal healthcare platform for glaucoma and other ocular diseases.
논문정보
- Research article
- 2022년 11월 (BRIC 등록일 2023-01-31)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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