한빛사논문
- 조회425
Gwang-Bum Im, Young Geon Kim, Tae Yong Yoo, Yeong Hwan Kim, Kang Kim, Jiyu Hyun, Min Soh,Taeghwan Hyeon*, Suk Ho Bhang*
G. B.Im, Y. H. Kim, J. Hyun, S. H. Bhang
School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea
G. B. Im
Present address: Department of Cardiac Surgery, Boston Children’s Hospitaland Harvard Medical School, Boston MA 02115, USA
Y.G. Kim, T.Y. Yoo, K. Kim, M. Soh, T. Hyeon
Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea
School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea
G.B.I., Y.G.K., and T.Y.Y. contributed equally to this work.
CORRESPONDING AUTHORS : Taeghwan Hyeon, Suk Ho Bhang
Abstract
All exogenous nanomaterials undergo rapid biotransformation once injected into body and fall short of executing the intended purpose. Here we report that copper-deposited ceria nanoparticles (CuCe NPs) exhibit enhanced antioxidant effects than pristine ceria nanoparticles as the released copper buffers the depletion of glutathione while providing the bioavailable copper as a cofactor for the antioxidant enzyme, superoxide dismutase 1. The upregulated intracellular antioxidants along with ceria nanoparticles synergistically scavenge reactive oxygen species and promote anti-inflammation and M2 polarization of macrophages by modulating STAT1 and STAT6. The therapeutic effect of CuCe NPs is demonstrated in ischemic vascular diseases (i.e., murine models of hindlimb ischemia and myocardial infarction) in which the copper-deposition affords increased perfusion and alleviation in tissue damages. The results provide rationale that metal oxide nanomaterials can be designed in a way to induce the upregulation of specific biological factors for optimal therapeutic performance.
논문정보
- Research article
- 2023년 01월 (BRIC 등록일 2023-01-30)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
관련분야 논문보기
