한빛사논문
- 조회463
Sung-Won Kim, Gwang-Bum Im, Yeong Hwan Kim, Suk Ho Bhang
School of Chemical Engineering, Sungkyunkwan University, Suwon, South Korea
Sung-Won Kim and Gwang-Bum Im contributed equally to this work.
Correspondence: Suk Ho Bhang
Abstract
We used a blue organic light-emitting diode (bOLED) to increase the paracrine factors secreted from human adipose-derived stem cells (hADSCs) for producing conditioned medium (CM). Our results showed that while the bOLED irradiation promotes a mild-dose reactive oxygen generation that enhances the angiogenic paracrine secretion of hADSCs, it does not induce phototoxicity. The bOLED enhances paracrine factors via a cell-signaling mechanism involving hypoxia-inducible factor 1 alpha. This study demonstrated that the CM resulting from bOLED treatment shows improved therapeutic effects on mouse wound-healing models. This method contributes to overcoming the barriers to stem-cell therapies, including the toxicity and low yields from other methods such as nanoparticles, synthetic polymers, and even cell-derived vesicles.
논문정보
- Research article
- 2022년 12월 (BRIC 등록일 2023-01-30)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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