한빛사논문
- 조회555
Ji Min Lee 1,4, Henrik M. Hammarén 2,4, Mikhail M. Savitski 2 & Sung Hee Baek 3
1Graduate School of Medical Science & Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
2Genome Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
3Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul 08826, Korea.
4These authors contributed equally: Ji Min Lee, Henrik M. Hammarén.
Corresponding author : Correspondence to Sung Hee Baek.
Abstract
Post-translational modifications (PTMs) can occur on specific amino acids localized within regulatory domains of target proteins, which control a protein’s stability. These regions, called degrons, are often controlled by PTMs, which act as signals to expedite protein degradation (PTM-activated degrons) or to forestall degradation and stabilize a protein (PTM-inactivated degrons). We summarize current knowledge of the regulation of protein stability by various PTMs. We aim to display the variety and breadth of known mechanisms of regulation as well as highlight common themes in PTM-regulated degrons to enhance potential for identifying novel drug targets where druggable targets are currently lacking.
논문정보
- Review Paper
- 2023년 01월 (BRIC 등록일 2023-01-17)
- 국내(교신)+국외 연구진
- 생명과학 > 세포생물학
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