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한빛사논문

조회364

연세대학교

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Biosens. Bioelectron., 2023 Jan 15;220:114912 | https://doi.org/10.1016/j.bios.2022.114912 Highly-sensitive single-step sensing of levodopa by swellable microneedle-mounted nanogap sensors

SeungHyun Park^a,1, Yong Jae Kim^a,c,1, Elisabeth Kostal^b, Volha Matylitskaya^b, Stefan Partel^b, WonHyoung Ryu^a

^aDepartment of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea
^bResearch Centre for Microtechnology, Vorarlberg University of Applied Sciences, 6850, Dornbirn, Austria
^cDepartment of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695, USA

¹These authors equally contributed to the paper.
Corresponding authors: Stefan Partel, WonHyoung Ryu

Abstract

Microneedle (MN) sensing of biomarkers in interstitial fluid (ISF) can overcome the challenges of self-diagnosis of diseases by a patient, such as blood sampling, handling, and measurement analysis. However, the MN sensing technologies still suffer from poor measurement accuracy due to the small amount of target molecules present in ISF, and require multiple steps of ISF extraction, ISF isolation from MN, and measurement with additional equipment. Here, we present a swellable MN-mounted nanogap sensor that can be inserted into the skin tissue, absorb ISF rapidly, and measure biomarkers in situ by amplifying the measurement signals by redox cycling in nanogap electrodes. We demonstrate that the MN-nanogap sensor measures levodopa (LDA), medication for Parkinson disease, down to 100 nM in an aqueous solution, and 1 μM in both the skin-mimicked gelatin phantom and porcine skin.

논문정보

형식Research article
게재일2023년 01월 (BRIC 등록일 2023-01-16)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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