한빛사논문
- 조회335
Jong An Lee1,2,6, Hyun Uk Kim2,3,4,6, Jeong-Geol Na5,6, Yoo-Sung Ko1,2, Jae Sung Cho1,2, Sang Yup Lee1,2,4
1Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), KAIST Institute for BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea
2Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, Daejeon 34141, Republic of Korea
3Systems Biology and Medicine Laboratory, Department of Chemical and Biomolecular Engineering, KAIST, Daejeon 34141, Republic of Korea
4BioProcess Engineering Research Center and BioInformatics Research Center, KAIST, Daejeon 34141, Republic of Korea
5Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 04107, Republic of Korea
6These authors contributed equally to this work.
Correspondence: Sang Yup Lee
Abstract
Sustainable production of chemicals and materials from renewable non-food biomass using biorefineries has become increasingly important in an effort toward the vision of ‘net zero carbon’ that has recently been pledged by countries around the world. Systems metabolic engineering has allowed the efficient development of microbial strains overproducing an increasing number of chemicals and materials, some of which have been translated to industrial-scale production. Fermentation is one of the key processes determining the overall economics of bioprocesses, but has recently been attracting less research attention. In this Review, we revisit and discuss factors affecting the competitiveness of bacterial fermentation in connection to strain development by systems metabolic engineering. Future perspectives for developing efficient fermentation processes are also discussed.
논문정보
- Review Paper
- 2022년 11월 (BRIC 등록일 2023-01-12)
- 국내 연구진
- 생명과학 > 응용생물화학
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