한빛사논문
- 조회253
Juyeong Hong1, Kexin Xu1 and Ji Hoon Lee 1
1Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Corresponding author: Correspondence to Ji Hoon Lee.
Abstract
The N6-Methyladenosine (m6A) modification of RNA transcripts is the most prevalent and abundant internal modification in eukaryotic messenger RNAs (mRNAs) and plays diverse and important roles in normal biological processes. Extensive studies have indicated that dysregulated m6A modification and m6A-associated proteins play critical roles in tumorigenesis and cancer progression. However, m6A-mediated physiological consequences often lead to opposite outcomes in a biological context-dependent manner. Therefore, context-related complexity must be meaningfully considered to obtain a comprehensive understanding of RNA methylation. Recently, it has been reported that m6A-modified RNAs are closely related to the regulation of the DNA damage response and genomic integrity maintenance. Here, we present an overview of the current knowledge on the m6A modification and its function in human cancer, particularly in relation to the DNA damage response and genomic instability.
논문정보
- Review Paper
- 2022년 11월 (BRIC 등록일 2023-01-11)
- 국외 연구진
- 생명과학 > 분자생물학
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