한빛사논문
- 조회1,100
Se-Chan Oh 1,2,10, Seong-Eun Kim 3,10, In-Hwan Jang1,2, Seok-Min Kim1,2, Soo Yun Lee1, Sunyoung Lee1,4, In-Sun Chu 5,6, Suk Ran Yoon1,2, Haiyoung Jung1,2, Inpyo Choi1, Junsang Doh 7 & Tae-Don Kim 1,2,8,9
1Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
2Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, Republic of Korea.
3Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.
4Department of Life Sciences, Korea University, Seoul, Republic of Korea.
5Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
6Department of Bioinformatics, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, Republic of Korea.
7Department of Materials Science and Engineering, Research Institute of Advanced Materials, Institute of Engineering Research, Bio-MAX Institute, Soft Foundry Institute, Seoul National University, Seoul, Republic of Korea.
8Biomedical Mathematics Group, Institute for Basic Science, Daejeon, Republic of Korea.
9Department of Biopharmaceutical Convergence, School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
10These authors contributed equally: Se-Chan Oh, Seong-Eun Kim
Corresponding authors: Correspondence to Junsang Doh or Tae-Don Kim.
Abstract
The formation of an immunological synapse (IS) is essential for natural killer (NK) cells to eliminate target cells. Despite an advanced understanding of the characteristics of the IS and its formation processes, the mechanisms that regulate its stability via the cytoskeleton are unclear. Here, we show that Nogo receptor 1 (NgR1) has an important function in modulating NK cell-mediated killing by destabilization of IS formation. NgR1 deficiency or blockade resulted in improved tumor control of NK cells by enhancing NK-to-target cell contact stability and regulating F-actin dynamics during IS formation. Patients with tumors expressing abundant NgR1 ligand had poor prognosis despite high levels of NK cell infiltration. Thus, our study identifies NgR1 as an immune checkpoint in IS formation and indicates a potential approach to improve the cytolytic function of NK cells in cancer immunotherapy.
논문정보
- Research article
- 2023년 01월 (BRIC 등록일 2023-01-10)
- 국내 연구진
- 생명과학 > 면역학
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