신재호 (Northwestern University)

한빛사논문

조회421

Northwestern University

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Adv. Healthc. Mater., 2022 Nov 7;e2202021 | https://doi.org/10.1002/adhm.202202021 Wireless, Soft Sensors of Skin Hydration with Designs Optimized for Rapid, Accurate Diagnostics of Dermatological Health

Jaeho Shin ¹, Heling Wang ^{2 3}, Kyeongha Kwon ^{1 4}, Diana Ostojich ⁵, Zach Christiansen ⁵, Jaime Berkovich ^{1 6}, Yoonseok Park ¹, Zhengwei Li ¹, Geumbee Lee ¹, Rania Nasif ^{1 7}, Ted S Chung ¹, Chun-Ju Su ¹, Jaeman Lim ¹, Hitoki Kubota⁸, Akihiko Ikoma ⁸, Yi-An Lu ⁵, Derrick H Lin ⁹, Shuai Xu ^{1 7 9}, Anthony Banks ^{1 5}, Jan-Kai Chang ^{1 5}, John A Rogers ^{1 6 7 10 11 12 13 14}

¹Querrey-Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA.
²Laboratory of Flexible Electronics Technology, Tsinghua University, Beijing, 100085, China.
³Institute of Flexible Electronics Technology of THU, Jiaxing, Zhejiang, 314006, China.
⁴School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
⁵Wearifi Inc., Evanston, IL, 60201, USA.
⁶Department of Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA.
⁷Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
⁸Maruho Co., Ltd., Osaka, 531-0071, Japan.
⁹Department of Dermatology, Northwestern University, Chicago, IL, 60611, USA.
¹⁰Department of Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA.
¹¹Department of Neurological Surgery, Northwestern University, Evanston, IL, 60208, USA.
¹²Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA.
¹³Department of Chemical Engineering, Northwestern University, Evanston, IL, 60208, USA.
¹⁴Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, 60208, USA.

CORRESPONDING AUTHOR : John A. Rogers

Abstract

Accurate measurements of skin hydration are of great interest to dermatological science and clinical practice. This parameter serves as a relevant surrogate of skin barrier function, a key representative benchmark for overall skin health. The skin hydration sensor (SHS) is a soft, skin-interfaced wireless system that exploits a thermal measurement method, as an alternative to conventional impedance-based hand-held probes. This study presents multiple strategies for maximizing the sensitivity and reliability of this previously reported SHS platform. An in-depth analysis of the thermal physics of the measurement process serves as the basis for structural optimizations of the electronics and the interface to the skin. Additional engineering advances eliminate variabilities associated with manual use of the device and with protocols for the measurement. The cumulative effect is an improvement in sensitivity by 135% and in repeatability by 36% over previously reported results. Pilot trials on more than 200 patients in a dermatology clinic validate the practical utility of the sensor for fast, reliable measurements.

논문정보

형식Research article
게재일2022년 11월 (BRIC 등록일 2023-01-10)
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