한빛사논문
- 조회311
Joseph Criscionea,1, Zahra Rezaeib,1, Carol M. Hernandez Cantub, Sean Murphya, Su Ryon Shinb, Deok-Ho Kima,c
aDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
bDivision of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA, USA
cDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
1Authors contributed equally to the preparation of this manuscript.
Corresponding authors: Su Ryon Shin, Deok-Ho Kim
Abstract
Heart disease is the leading cause of death worldwide and imposes a significant burden on healthcare systems globally. A major hurdle to the development of more effective therapeutics is the reliance on animal models that fail to faithfully recapitulate human pathophysiology. The predictivity of in vitro models that lack the complexity of in vivo tissue remain poor as well. To combat these issues, researchers are developing organ-on-a-chip models of the heart that leverage the use of human induced pluripotent stem cell-derived cardiomyocytes in combination with novel platforms engineered to better recapitulate tissue- and organ-level physiology. The integration of novel biosensors into these platforms is also a critical step in the development of these models, as they allow for increased throughput, real-time and longitudinal phenotypic assessment, and improved efficiency during preclinical disease modeling and drug screening studies. These platforms hold great promise for both improving our understanding of heart disease as well as for screening potential therapeutics based on clinically relevant endpoints with better predictivity of clinical outcomes. In this review, we describe state-of-the-art heart-on-a-chip platforms, the integration of novel biosensors into these models for real-time and continual monitoring of tissue-level physiology, as well as their use for modeling heart disease and drug screening applications. We also discuss future perspectives and further advances required to enable clinical trials-on-a-chip and next-generation precision medicine platforms.
논문정보
- Review Paper
- 2023년 01월 (BRIC 등록일 2023-01-06)
- 국외 연구진
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