한빛사논문
- 조회308
Hui Li,‡a Yujun Kim,‡a Hyoje Jung,a Ji Young Hyun*b and Injae Shin*a
a Department of Chemistry, Yonsei University, 03722 Seoul, Republic of Korea.
b Department of Drug Discovery, Data Convergence Drug Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea.
‡ These two authors equally contributed to this study.
* Corresponding authors : Injae Shin, Ji Young Hyun
Abstract
Near-infrared (NIR) fluorophores have unique features that endow them with several advantages over conventional shorter wavelength emitting dyes. As a result, they have been widely utilized as fluorescence and photoacoustic imaging agents, as well as photodynamic and photothermal therapeutic agents. However, non-targeting NIR fluorescence-emitting organic molecules have the drawback of low selectivity toward tumors, which potentially results in severe side effects caused by damage to normal tissues. Thus, the development of NIR fluorophore-based substances that target tumors is a highly active area in medicinal chemistry research. Research efforts carried out thus far have led to the development of a number of NIR fluorophore-based, tumor imaging and therapeutic agents. The discussion in this review focuses on the results of research reported in the 2012–2021 period, giving particular emphasis to studies of NIR small organic dye-based imaging and therapeutic agents that are designed utilizing cancer-selective strategies.
논문정보
- Review Paper
- 2022년 10월 (BRIC 등록일 2023-01-04)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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