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건국대학교

Clin. Immunol., Volume 246, January 2023, 109215 | https://doi.org/10.1016/j.clim.2022.109215 Sialylated IVIg binding to DC-SIGN+ Hofbauer cells induces immune tolerance through the caveolin-1/NF-kB pathway and IL-10 secretion

Hyeongjwa Choi^a,1, Seung-Woo Yang^b,1, Jin-Soo Joo^a,c, Min Park^a, Yihua Jin^a, Ji-Woon Kim^a, Seon-Yeong Lee^d, Sung-Vin Lee^c, Tae-Jin Yun^e, Mi-La Cho^d,f, Han-Sung Hwang^g, Young-Sun Kang^a,c,h

^aDepartment of KONKUK-KIST Biomedical Science & Technology, Konkuk University; 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea
^bDepartment of Obstetrics and Gynecology, Sang-Gye Paik Hospital, Inje University School of Medicine; Seoul 01757, Republic of Korea
^cDepartment of Veterinary Pharmacology and Toxicology, Veterinary Science Research Institute, College of Veterinary Medicine, Konkuk University; 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea
^dThe Rheumatism Research Center, The Catholic University of Korea, Seoul, South Korea
^eDepartment of Pathology, New York University Grossman School of Medicine; New York, NY 10016, USA
^fDepartment of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, South Korea
^gDivision of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine; Seoul, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea
^hKU Research Center for Zoonosis, Konkuk University; 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea

Corresponding authors: Han-Sung Hwang, Young-Sun Kang

Abstract

Although the use of IVIg has increased in various immune-driven diseases and even in pregnancy, the exact action mechanisms of IVIg are not fully understood. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN) is a known receptor for α-2,6-sialylated IgG (sIVIg), which is responsible for the anti-inflammatory effect of IVIg. DC-SIGN is expressed on Hofbauer cells (HBCs) of the fetal villi of the placenta which act as an innate immune modulator at the maternal-fetal interface. Preeclampsia is a major complication in pregnancy and is related to IL-10, a cytokine with an important role in immune tolerance. DC-SIGN interaction with sIVIg in HBCs promoted IL-10 secretion through the activation of the caveolin-1/NF-κB pathway, especially in plasma lipid rafts. Consistent results were obtained for HBCs from patients with preeclampsia. Collectively, the stimulation of DC-SIGN+ HBCs with sIVIg enhanced immune tolerance in the feto-maternal environment, suggesting the therapeutic application of sIVIg to prevent preeclampsia.

논문정보

형식Research article
게재일2023년 01월 (BRIC 등록일 2023-01-03)
연구진국내(교신)+국외 연구진
분야 의약학 > 면역의학

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