한빛사논문
- 조회276
Geumbee Lee1,2†, Emily Ray3,4†, Hong-Joon Yoon1†, Sabrina Genovese4, Yeon Sik Choi1, Min-Kyu Lee1, Samet Şahin1,5, Ying Yan4, Hak-Young Ahn1, Amay J. Bandodkar6,7, Joohee Kim1, Minsu Park1, Hanjun Ryu8, Sung Soo Kwak9, Yei Hwan Jung10, Arman Odabas4,11, Umang Khandpur4, Wilson Z. Ray3,4, Matthew R. MacEwan3,4*, John A. Rogers1,12,13,14,15*
1Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
2Precision Biology Research Center, Sungkyunkwan University, Suwon 16419, Republic of Korea.
3Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
4Department of Neurological Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
5Department of Bioengineering, Bilecik Şeyh Edebali University, 11230 Bilecik, Merkez/Bilecik, Turkey.
6Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC 27606, USA.
7Center for Advanced Self-Powered Systems of Integrated Sensors and Technologies (ASSIST), North Carolina State University, Raleigh, NC 27606, USA.
8Department of Advanced Materials Engineering, Chung-Ang University, Anseong 17546, Republic of Korea.
9Center for Bionics, Biomedical Research Division, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
10Department of Electronic Engineering, Hanyang University, Seoul 04763, Republic of Korea.
11Department of Internal Medicine, Stanford University Medical Center, Stanford, CA 94305, USA.
12Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
13Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.
14De-partment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
15Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Corresponding authors: M.R.M.; J.A.R.
†These authors contributed equally to this work.
Abstract
Local electrical stimulation of peripheral nerves can block the propagation of action potentials, as an attractive alternative to pharmacological agents for the treatment of acute pain. Traditional hardware for such purposes, however, involves interfaces that can damage nerve tissue and, when used for temporary pain relief, that impose costs and risks due to requirements for surgical extraction after a period of need. Here, we introduce a bioresorbable nerve stimulator that enables electrical nerve block and associated pain mitigation without these drawbacks. This platform combines a collection of bioresorbable materials in architectures that support stable blocking with minimal adverse mechanical, electrical, or biochemical effects. Optimized designs ensure that the device disappears harmlessly in the body after a desired period of use. Studies in live animal models illustrate capabilities for complete nerve block and other key features of the technology. In certain clinically relevant scenarios, such approaches may reduce or eliminate the need for use of highly addictive drugs such as opioids.
논문정보
- Research article
- 2022년 10월 (BRIC 등록일 2023-01-27)
- 국내+국외 연구진
- 바이오·의료융합 > 바이오소재
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