한빛사논문
- 조회537
Suyeong Seo, Minjeong Jang, Hwieun Kim, Jong Hwan Sung,* Nakwon Choi,* Kangwon Lee,* and Hong Nam Kim*
S. Seo, M. Jang, H. Kim, N. Choi, H. N. Kim
Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
S. Seo
Program in Nano Science and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea
H. Kim, J. H. Sung
Department of Chemical Engineering, Hongik University, Seoul 04066, Republic of Korea
N. Choi
KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea
N. Choi
Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul 02792, Republic of Korea
K. Lee
Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea
K. Lee
Research Institute for Convergence Science, Seoul National University, Seoul 08826, Republic of Korea
H. N. Kim
School of Mechanical Engineering, Yonsei University, Seoul 03722, Republic of Korea
H. N. Kim
Yonsei-KIST Convergence Research Institute, Yonsei University, Seoul 03722, Republic of Korea
S.S. and M.J. contributed equally to this work.
J.H.S., N.C., K.L., and H.N.K. supervised the overall study.
CORRESPONDING AUTHORS: Jong Hwan Sung, Nakwon Choi, Kangwon Lee, Hong Nam Kim
Abstract
Air pollution induces neurodegeneration, including cognitive deficits, neuroinflammation, and disruption of the blood–brain barrier. The mechanisms underlying air pollution-mediated neurodegeneration have not yet been fully elucidated given the limited knowledge on intercellular interactions. A brain-on-a-chip platform is presented comprising neurons, glia, and brain endothelial cells (bECs; neuro-glia-vascular, NGV) and diesel exhaust particle (DEP)-induced neurodegeneration is evaluated with a particular focus on the intercellular interactions. DEP exposure in the NGV model yields Alzheimer's disease-like signatures, including amyloid beta accumulation, tau phosphorylation, hydrogen peroxide (H2O2)/reactive oxygen species (ROS) production, and neuronal cell death. bEC-secreted granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates microglial activation and the overproduction of H2O2/ROS in microglia, suggesting that the bEC-microglia-neuron is a neurodegeneration cascade. Pharmacological inhibition at each step of the cascade, including GM-CSF neutralization, microglial activation suppression, and ROS scavenging, prohibits neurodegeneration in the NGV model. Therefore, intercellular interactions should be further studied of air pollution-induced neurodegeneration.
논문정보
- Research article
- 2022년 12월 (BRIC 등록일 2022-12-30)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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