한빛사논문
- 조회595
Yeonjin Je 1, Kyungdo Han 2, Jaeyoung Chun 1, Yuna Kim 1, Jie-Hyun Kim 1, Young Hoon Youn 1, Hyojin Park 1, Jong Pil Im 3, Joo Sung Kim 3
1Division of Gastroenterology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
2Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea.
3Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Correspondence: Jaeyoung Chun
Abstract
Background and aims: Metabolic syndrome may share the pathophysiology of adipose tissue dysregulation and inadequate immune response with inflammatory bowel disease (IBD). We determined the association of abdominal obesity (AO) with the risk of developing IBD.
Methods: We conducted a nationwide population-based cohort study using the Korean National Health Insurance Services database. A total of 10,082,568 participants of the 2009 national health screening program were enrolled. Newly diagnosed Crohn's disease (CD) and ulcerative colitis (UC) were identified using the international classification of diseases 10th revision and specialized national codes for rare intractable diseases. Waist circumference (WC) was classified into 6 groups and compared with the references of 85.0-89.9 cm for men and 80.0-84.9 cm for women. AO was defined as a WC of ≥90 cm for men and ≥85 cm for women.
Results: During a median follow-up of 9.3 years, the incidence rates of CD and UC were 2.11 and 8.40 per 100,000 person-years, respectively. After adjustment for age, sex, lifestyle behaviors, income and body mass index (BMI), the increase in baseline WC was significantly associated with the risk of developing CD, but not UC, compared to the references. The risk of developing CD in subjects with AO increased significantly compared to those without AO (adjusted hazard ratio, 1.40; 95% confidence interval, 1.21-1.61), regardless of obesity based on BMI.
Conclusions: Individuals with AO bore an increased risk of developing CD proportional to WC, but not UC, suggesting that visceral adiposity is related to the pathophysiology of CD.
논문정보
- Research article
- 2022년 12월 (BRIC 등록일 2022-12-29)
- 국내 연구진
- 의약학 > 응용의학
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