한빛사논문
- 조회508
Yehhyun Jo 1, Sang-Mok Lee 1, Taesub Jung 2, Gijae Park 3, Chanhee Lee 4, Geun Ho Im 4, Seongju Lee 5, Jin Soo Park 3 6, Chaerin Oh 1, Geon Kook 1, Hyunggug Kim 1, Seongyeon Kim 1, Byung Chul Lee 6, Greg S B Suh 5, Seong-Gi Kim 4 7 8, Jeongyeon Kim 2, Hyunjoo J Lee 1 9
1School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
2Korea Brain Research Institute (KBRI), Daegu, 41068, Republic of Korea.
3Department of Electrical Engineering, Korea University, Seoul, 02841, Republic of Korea.
4Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, 16419, Republic of Korea.
5Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
6Creative Research Center for Brain Science, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
7Department of Biomedical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
8Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
9KAIST Institute for Health Science and Technology (KIHST), Daejeon, 34141, Republic of Korea.
CORRESPONDING AUTHORS: Jeongyeon Kim, Hyunjoo J Lee
Abstract
Transcranial focused ultrasound stimulation (tFUS) is an effective noninvasive treatment modality for brain disorders with high clinical potential. However, the therapeutic effects of ultrasound neuromodulation are not widely explored due to limitations in preclinical systems. The current preclinical studies are head-fixed, anesthesia-dependent, and acute, limiting clinical translatability. Here, this work reports a general-purpose ultrasound neuromodulation system for chronic, closed-loop preclinical studies in freely behaving rodents. This work uses microelectromechanical systems (MEMS) technology to design and fabricate a small and lightweight transducer capable of artifact-free stimulation and simultaneous neural recording. Using the general-purpose system, it can be observed that state-dependent ultrasound neuromodulation of the prefrontal cortex increases rapid eye movement (REM) sleep and protects spatial working memory to REM sleep deprivation. The system will allow explorative studies in brain disease therapeutics and neuromodulation using ultrasound stimulation for widespread clinical adoption.
논문정보
- Research article
- 2022년 12월 (BRIC 등록일 2022-12-23)
- 국내 연구진
- 바이오·의료융합 > 뇌인지과학
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