한빛사논문
- 조회398
Eun Ha Leea,b*, Hyun Kimc*, Jung Hee Kohd,e*, Kwang Hyun Chaa, Kiseok Keith Leec**, Wan-Uk Kimd,e, Cheol-Ho Pana, and Yong-Hwan Leeb,c,f,g,h
aNatural Product Informatics Research Center, KIST Gangneung Institute of Natural Products, Gangneung, Korea;
bInterdisciplinary Program in Agricultural Genomics, Seoul National University, Seoul, Korea;
cDepartment of Agricultural Biotechnology, Seoul National University, Seoul, Korea;
dDivision of Rheumatology, Department of Internal Medicine, College of Medicine, the Catholic University of Korea, Seoul, Korea;
eCenter for Integrative Rheumatoid Transcriptomics and Dynamics, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea;
fCenter for Plant Microbiome Research, Seoul National University, Seoul, Korea;
gPlant Immunity Research Center, Seoul National University, Seoul, Korea;
hResearch Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Korea
CONTACT Wan-Uk Kim
*These authors contributed equally contributed this work.
**Present address: Department of Ecology and Evolution, The University of Chicago, 1101 East 57th Street, Chicago, IL, 60637 USA
Abstract
Rheumatoid arthritis (RA) is closely associated with the oral and gut microbiomes. Fungal cell wall components initiate inflammatory arthritis in mouse models. However, little is known regarding the role of the fungal community in the pathogenesis of RA. To evaluate the association between RA and the gut microbiome, investigations of bacterial and fungal communities in patients with RA are necessary. Therefore, we investigated the compositions and associations of fecal bacterial and fungal communities in 30 healthy controls and 99 patients with RA. The relative abundances of Bifidobacterium and Blautia decreased, whereas the relative abundance of Streptococcus increased, in patients with RA. The relative abundance of Candida in the fecal fungal community was higher in patients with RA than in healthy controls, while the relative abundance of Aspergillus was higher in healthy controls than in patients with RA. Candida species-specific gene amplification showed that C. albicans was the most abundant species of Candida. Ordination analysis and random forest classification models supported the findings of structural changes in bacterial and fungal communities. Aspergillus was the core fecal fungal genus in healthy controls, although Saccharomyces spp. are typically predominant in Western cohorts. In addition, bacterial–fungal association analyses showed that the hub node had shifted from fungi to bacteria in patients with RA. The finding of fungal dysbiosis in patients with RA suggests that fungi play critical roles in the fecal microbial communities and pathogenesis of RA.
논문정보
- Research article
- 2022년 12월 (BRIC 등록일 2022-12-21)
- 국내 연구진
- 생명과학 > 유전학
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