한빛사논문
- 조회309
Seok Jong Chung, MD, PhD*, Yae Ji Kim, BS*, Yun Joong Kim, MD, PhD, Hye Sun Lee, PhD, Seong Ho Jeong, MD, Ji-Man Hong, MD, PhD, Young H. Sohn, MD, PhD, Mijin Yun, MD, PhD, Yong Jeong, MD, PhD† and Phil Hyu Lee, MD, PhD†
From the Department of Neurology (S.J.C., Yun Joong Kim, Y.H.S., P.H.L.), Yonsei University College of Medicine, Seoul, South Korea; Department of Neurology (S.J.C., Yun Joong Kim), Yongin Severance Hospital, Yonsei University Health System, Yongin, South Korea; Program of Brain and Cognitive Engineering (Yae Ji Kim, Y.J.), Korea Advanced Institute of Science and Technology, Daejeon, South Korea; KI for Health Science and Technology (Yae Ji Kim, Y.J.), Korea Advanced Institute of Science and Technology, Daejeon, South Korea; Biostatistics Collaboration Unit (H.S.L.), Yonsei University College of Medicine, Seoul, South Korea; Department of Neurology (S.H.J.), Sanggye Paik Hospital, Inje University College of Medicine, Seoul, South Korea; Department of Nuclear Medicine (M.Y.), Yonsei University College of Medicine, Seoul, South Korea; Department of Bio and Brain Engineering (Y.J.), Korea Advanced Institute of Science and Technology, Daejeon, South Korea; and Severance Biomedical Science Institute (P.H.L.), Yonsei University College of Medicine, Seoul, South Korea.
* These authors contributed equally to this work as first authors.
† These authors contributed equally to this work as senior authors.
Correspondence: Phil Hyu Lee, MD, PhD
Abstract
Objectives: Individual variability in nigrostriatal dopaminergic denervation is an important factor underlying clinical heterogeneity in Parkinson's disease (PD). This study aimed to explore whether the pattern of striatal dopamine depletion was associated with white matter (WM) networks in PD.
Methods: A total of 240 newly diagnosed PD patients who underwent 18F-FP-CIT PET scans and brain diffusion tensor imaging at initial assessment were enrolled in this study. We measured 18F-FP-CIT tracer uptake as an indirect marker for striatal dopamine depletion. Factor analysis-derived striatal dopamine loss patterns were estimated in each patient to calculate the composite scores of four striatal subregion factors (caudate, more- and less-affected sensorimotor striata, and anterior putamen) based on the availability of striatal dopamine transporter. The WM structural networks that were correlated with the composite scores of each striatal subregion factor were identified using a network-based statistic analysis.
Results: A higher composite score of caudate (i.e., relatively preserved dopaminergic innervation in the caudate) was associated with a strong structural connectivity in a single subnetwork comprising the left caudate and left frontal gyri. Selective dopamine loss in the caudate was associated with strong connectivity in the structural subnetwork whose hub nodes were bilateral thalami and left insula, which were connected to the anterior cingulum. However, no subnetworks were correlated with the composite scores of other striatal subregion factors. The connectivity strength of the network with a positive correlation with the composite score of caudate affected the frontal/executive function either directly or indirectly through the mediation of dopamine depletion in the caudate.
논문정보
- Research article
- 2022년 12월 (BRIC 등록일 2022-12-29)
- 국내 연구진
- 의약학 > 신경의학
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