한빛사논문
- 조회626
DoYeun Park1,2,8, Donghak Kim1,2,8, Su Jeong Park1,2,8, Jeong Ho Choi3, Yoojin Seo4, Dong-Hwee Kim 1, Sang-Hoon Lee1,5,9, Jung Keun Hyun3, Jin Yoo2, Youngmee Jung 2,6 and Soo Hyun Kim1,2,7
1KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
2Center for Biomaterials Research Center, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
3Institute of Tissue Regeneration Engineering,Dankook University, Cheonan 31114, Republic of Korea.
4Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
5School of Biomedical Engineering, College of Health Science, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
6School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, Republic of Korea.
7Korea Institute of Science and Technology (KIST) Europe, Campus E7.1, 66123 Saarbrücken, Germany.
8These authors contributed equally: DoYeun Park, Donghak Kim, Su Jeong Park.
9Deceased: Sang-Hoon Lee.
Corresponding authors :Correspondence to Youngmee Jung or Soo Hyun Kim.
Abstract
Guiding the regrowth of thousands of nerve fibers within a regeneration-friendly environment enhances the regeneration capacity in the case of peripheral nerve injury (PNI) and spinal cord injury (SCI). Although clinical treatments are available and several studies have been conducted, the development of nerve guidance conduits (NGCs) with desirable properties, including controllable size, hundreds of nerve bundle-sized microchannels, and host stem-cell recruitment, remains challenging. In this study, the micropattern-based fabrication method was combined with stem-cell recruitment factor (substance P, SP) immobilization onto the main material to produce a size-tunable NGC with hundreds of microchannels with stem-cell recruitment capability. The SP-immobilized multiple microchannels aligned the regrowth of nerve fibers and recruited the host stem cells, which enhanced the functional regeneration capacity. This method has wide applicability in the modification and augmentation of NGCs, such as bifurcated morphology or directional topographies on microchannels. Additional improvements in fabrication will advance the regeneration technology and improve the treatment of PNI/SCI.
논문정보
- Research article
- 2022년 10월 (BRIC 등록일 2022-12-21)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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