한빛사논문
- 조회274
KAIST
Jae Hee Lee 1, Yuri Ahn 2, Han Eol Lee 1 3, You Na Jang 4, A Yeon Park 4, Shinho Kim 5, Young Hoon Jung 1, Sang Hyun Sung 1, Jung Ho Shin 1, Seung Hyung Lee 1, Sang Hyun Park 1, Ki Soo Kim 6, Min Seok Jang 5, Beom Joon Kim 4, Sang Ho Oh 2, Keon Jae Lee 1
1Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
2Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
3Division of Advanced Materials Engineering, Jeonbuk National University, 567 Baekje-Daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896, Republic of Korea.
4Department of Dermatology, Chung-Ang University Hospital, 224-1 Heukseok-dong, Dongjak-gu, Seoul, 156-755, Republic of Korea.
5School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
6Fronics Co., Ltd., 754, Seolleung-ro, Gangnam-gu, Seoul, 06062, Republic of Korea.
CORRESPONDING AUTHOR: Keon Jae Lee
Abstract
Wearable light-emitting diode (LED)-based phototherapeutic devices have recently attracted attention as skin care tools for wrinkles, acne, and hyperpigmentation. However, the therapeutic effectiveness and safety of LED stimulators are still controversial due to their inefficient light transfer, high heat generation, and non-uniform spot irradiation. Here, a wearable surface-lighting micro-LED (SµLED) photostimulator is reported for skin care and cosmetic applications. The SµLEDs, consisting of a light diffusion layer (LDL), 900 thin film µLEDs, and polydimethylsiloxane (PDMS), achieve uniform surface-lighting in 2 × 2 cm2-sized area with 100% emission yields. The SµLEDs maximize photostimulation effectiveness on the skin surface by uniform irradiation, high flexibility, and thermal stability. The SµLED's effect on melanogenesis inhibition is evaluated via in vitro and in vivo experiments to human skin equivalents (HSEs) and mouse dorsal skin, respectively. The anti-melanogenic effect of SµLEDs is confirmed by significantly reduced levels of melanin contents, melan-A, tyrosinase, and microphthalmia-associated transcription factor (MITF), compared to a conventional LED (CLED) stimulator.
논문정보
- Research article
- 2022년 10월 (BRIC 등록일 2023-01-26)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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