한빛사논문
- 조회286
Jong Eun Lee*, Kum Ju Chae*, Young Ju Suh, Won Gi Jeong, Taebum Lee, Yun-Hyeon Kim, Gong Yong Jin, Yeon Joo Jeong1
From the Departments of Radiology (J.E.L., Y.H.K.) and Pathology (T.L.), Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea; Department of Radiology, Research Institute of Clinical Medicine of Jeonbuk National University–Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea (K.J.C., G.Y.J.); Department of Biomedical Sciences, School of Medicine, Inha University, Incheon, Korea (Y.J.S.); Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea (W.G.J.); and Department of Radiology and Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea (Y.J.J.).
* J.E.L. and K.J.C. contributed equally to this work.
1 Address correspondence to Y.J.J.
Abstract
Background
The association between interstitial lung abnormalities (ILAs) and long-term outcomes has not been reported in Asian health screening populations.
Purpose
To investigate ILA prevalence in an Asian health screening cohort and determine rates and risks for ILA progression, lung cancer development, and mortality within the 10-year follow-up.
Materials and Methods
This observational, retrospective multicenter study included patients aged 50 years or older who underwent chest CT at three health screening centers over a 4-year period (2007–2010). ILA status was classified as none, equivocal ILA, and ILA (nonfibrotic or fibrotic). Progression was evaluated from baseline to the last follow-up CT examination, when available. The log-rank test was performed to compare mortality rates over time between ILA statuses. Multivariable Cox proportional hazards models were used to assess factors associated with hazards of ILA progression, lung cancer development, and mortality.
Results
Of the 2765 included patients (mean age, 59 years ± 7 [SD]; 2068 men), 94 (3%) had a finding of ILA (35 nonfibrotic and 59 fibrotic ILA) and 119 (4%) had equivocal ILA. The median time for CT follow-up and the entire observation was 8 and 12 years, respectively. ILA progression was observed in 80% (48 of 60) of patients with ILA over 8 years. Those with fibrotic and nonfibrotic ILA had a higher mortality rate than those without ILA (P < .001 and P = .01, respectively) over 12 years. Fibrotic ILA was independently associated with ILA progression (hazard ratio [HR], 10.3; 95% CI: 6.4, 16.4; P < .001), lung cancer development (HR, 4.4; 95% CI: 2.1, 9.1; P < .001), disease-specific mortality (HR, 6.7; 95% CI: 3.7, 12.2; P < .001), and all-cause mortality (HR, 2.5; 95% CI: 1.6, 3.8; P < .001) compared with no ILA.
Conclusion
The prevalence of interstitial lung abnormalities (ILAs) in an Asian health screening cohort was approximately 3%, and fibrotic ILA was an independent risk factor for ILA progression, lung cancer development, and mortality.
논문정보
- Research article
- 2022년 10월 (BRIC 등록일 2023-01-30)
- 국내 연구진
- 의약학 > 응용의학
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