한빛사논문
- 조회359
Yen N. Diepa,b,c, Tae Jin Kimd, Hansang Choa,b,c, Luke P. Leea,b,e,f,g,h
aInstitute of Quantum Biophysics, Sungkyunkwan University, Suwon 16419, Republic of Korea
bDepartment of Biophysics, Sungkyunkwan University, Suwon 16419, Republic of Korea
cDepartment of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea
dDepartment of Immunology, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea
eDepartment of Bioengineering, University of California at Berkeley, Berkeley 94720, CA, USA
fDepartment of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley 94720, CA, USA
gBiophysics Graduate Program, University of California at Berkeley, Berkeley 94720, CA, USA
hDepartment of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Boston 02115, MA, USA
Corresponding authors : Tae Jin Kim, Hansang Cho, Luke P. Lee
Abstract
Immunotherapy has emerged as a powerful strategy for liquid tumors to overcome the limitations of conventional cancer therapies. The nanomedical delivery system offers the possibility of enhancing cancer immunotherapy and expanding it to solid tumors. Here, we discuss the applications of medical nanoparticles to improve the efficacy of immunotherapy. We first focus on nanomedical particles used in cancer immunotherapy to deliver peptide and mRNA vaccines to the lymph nodes; and the exosome-based therapeutic cancer vaccine. Next, we highlight the applications of nanomedicine in immune checkpoint therapy to prolong the therapeutic effects, enhance tumor-targeting ability, and overcome drug resistance. We also evaluate the roles of nanomedical particles in oncolytic viral treatment, enabling the systemic injection of viruses or oncolytic plasmids/oncotoxic proteins; and virus entry in a receptor-independency manner. Lastly, we focus on nanoparticles in chimeric antigen receptor (CAR) T cell therapy to engineer CAR T cells, enhancing T cell proliferation and infiltration. We envision the nanomedical particles enhancing the therapeutic effects of immunotherapy and revolutionizing cancer therapy in the foreseeable future.
논문정보
- Review Paper
- 2022년 11월 (BRIC 등록일 2022-12-14)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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