한빛사논문
- 조회521
Kwangjin Park1,2,3,4 and Michel R Leroux *,1,2
1Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
2Centre for Cell Biology, Development, and Disease, Simon Fraser University, Burnaby, BC, Canada
3Present address: Terry Fox Laboratory, BC Cancer, Vancouver, BC, Canada
4Present address: Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
*Corresponding author : Michel R Leroux
Abstract
The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its environment. Acquiring these functions required the compartmentalization of a dynein-based motility apparatus and signaling proteins within a discrete subcellular organelle contiguous with the cytosol. Here, we explore the potential molecular mechanisms for how the proximal-most region of the cilium, termed transition zone (TZ), acts as a diffusion barrier for both membrane and soluble proteins and helps to ensure ciliary autonomy and homeostasis. These include a unique complement and spatial organization of proteins that span from the microtubule-based axoneme to the ciliary membrane; a protein picket fence; a specialized lipid microdomain; differential membrane curvature and thickness; and lastly, a size-selective molecular sieve. In addition, the TZ must be permissive for, and functionally integrates with, ciliary trafficking systems (including intraflagellar transport) that cross the barrier and make the ciliary compartment dynamic. The quest to understand the TZ continues and promises to not only illuminate essential aspects of human cell signaling, physiology, and development, but also to unravel how TZ dysfunction contributes to ciliopathies that affect multiple organ systems, including eyes, kidney, and brain.
논문정보
- Review Paper
- 2022년 12월 (BRIC 등록일 2022-12-13)
- 국외 연구진
- 생명과학 > 세포생물학
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