한빛사논문
- 조회381
Pengzhan Wang 1, Le Yu 2, Jiankang Gong 1, Jianhua Xiong 3, Soyu Zi 2, Hua Xie 4, Fan Zhang 1, Zhiqiang Mao 1 2, Zhihong Liu 1 3, Jong Seung Kim 2
1Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, China.
2Department of Chemistry, Korea University, Seoul, 02841, Korea.
3College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China.
4School of Water Resources and Hydropower, Wuhan University, Wuhan, Hubei 430072, China.
CORRESPONDING AUTHORS : Dr. Zhiqiang Mao, Prof. Zhihong Liu, Prof. Jong Seung Kim
Abstract
Peroxynitrite (ONOO- ) plays a critical role in Alzheimer's disease (AD). To reveal the ONOO- influx in AD brains, an activatable activity-based fluorescence probe Rd-DPA3 was designed by a structure-modulated strategy. Taking advantage of ONOO- -initiated two-step cascade reactions of a novel chemical trigger, Rd-DPA3 specifically responds to ONOO- in 0.3 mM of other reactive oxygen species (ROS) and varied proteins, and gives an intensive fluorescence enhancement (F/F0 =50). Moreover, with its mitochondria-targeting ability, Rd-DPA3 can be used to efficiently monitor the alternations of intracellular ONOO- levels in cerebral cells during oxidative stress. Significantly, due to NIR emission and good blood-brain barrier (BBB) crossing ability, Rd-DPA3 is suitable for in vivo imaging of cerebral ONOO- influx and illustrating an age-dependent accumulation of ONOO- in AD mice brains.
논문정보
- Research article
- 2022년 09월 (BRIC 등록일 2022-12-08)
- 국내(교신)+국외 연구진
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