한빛사논문
- 조회893
Ji An Kang1,2,3,4, Yoon Jung Kim1,2,3,4 and Young Joo Jeon 1,3
1Department of Biochemistry, Chungnam National University College of Medicine, Daejeon 35015, Korea.
2Brain Korea 21 FOUR Project for Medical Science, Chungnam National University, Daejeon 35015, Korea.
3Department of Medical Science, Chungnam National University College of Medicine, Daejeon 35015, Korea.
4These authors contributed equally: Ji An Kang, Yoon Jung Kim.
Corresponding author: Correspondence to Young Joo Jeon.
Abstract
ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like protein (UBL), which plays multifaceted roles not only as a free intracellular or extracellular molecule but also as a post-translational modifier in the process of ISG15 conjugation (ISGylation). ISG15 has only been identified in vertebrates, indicating that the functions of ISG15 and its conjugation are restricted to higher eukaryotes and have evolved with IFN signaling. Despite the highlighted complexity of ISG15 and ISGylation, it has been suggested that ISG15 and ISGylation profoundly impact a variety of cellular processes, including protein translation, autophagy, exosome secretion, cytokine secretion, cytoskeleton dynamics, DNA damage response, telomere shortening, and immune modulation, which emphasizes the necessity of reassessing ISG15 and ISGylation. However, the underlying mechanisms and molecular consequences of ISG15 and ISGylation remain poorly defined, largely due to a lack of knowledge on the ISG15 target repertoire. In this review, we provide a comprehensive overview of the mechanistic understanding and molecular consequences of ISG15 and ISGylation. We also highlight new insights into the roles of ISG15 and ISGylation not only in physiology but also in the pathogenesis of various human diseases, especially in cancer, which could contribute to therapeutic intervention in human diseases.
논문정보
- Review Paper
- 2022년 11월 (BRIC 등록일 2022-12-07)
- 국내 연구진
- 생명과학 > 생화학
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