한빛사논문
- 조회401
Hao Xiong1,2,4, Yunjie Xu1,3,4, Byungkook Kim1, Hyeonji Rha1, Bin Zhang3, Mingle Li1, Guang-Fu Yang2, Jong Seung Kim1
1Department of Chemistry, Korea University, Seoul 02841, Korea
2Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology & Health, Department of Chemistry, Central China Normal University, Wuhan 430079, P.R. China
3Institute of Translational Medicine, Institute of Microscale Optoelectronics, First Affiliated Hospital (Shenzhen Second People’s Hospital), Health Science Center, Shenzhen University, Shenzhen 518035, China
4These authors contributed equally
Corresponding authors: Mingle Li, Guang-Fu Yang, Jong Seung Kim
Abstract
Photochemical tools have revolutionized the landscape of biomedicine, enabling the exploration of nature in a noninvasively remote-controlled manner. Among them, especially appealing is the photocage. Recently, significant breakthroughs in photocages have been achieved in drug delivery systems, optical-controlled protein degradation, and RNA modulation. However, existing photocages have mostly centered on excitation in the ultraviolet-visible range, which has limited penetration depth, thus hindering their practical applications. In contrast, deep red or NIR light within the “phototherapeutic window” (650–900 nm) has unique advantages, such as minimized side effects and superior deep-tissue penetration. Nevertheless, strategies to rationally design such photocages and their underlying photochemical mechanisms of action remain elusive. Here, we plan to provide a comprehensive overview of recent advances of photocages in the phototherapeutic window, including their design principles, photocaging performance, photoactivation mechanism, and emerging utilizations in biomedical chemistry. It is hoped that this review will inspire the future development of photocage-related research.
논문정보
- Review Paper
- 2022년 12월 (BRIC 등록일 2022-12-05)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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